"Human and Non-Human Primate Genetics in the Post-Genomic Era"
2008 American Association of Anthropological Genetics Symposium (co-sponsored by the American Association of Physical Anthropologists), April 12, 2008, Columbus, Ohio
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Organizers and Co-Chairs: RAVINDRANATH DUGGIRALA and LORENA M. HAVILL, Southwest Foundation for Biomedical Research, San Antonio, TX.
In recent years, progress in understanding the genetic architecture of normal and disease-related complex phenotypes has been phenomenal, fueled by the explosion of research activities related to the Human Genome Project, non-human primate comprehensive sequencing projects, molecular genetics, and statistical genetics. The gene mapping and genomics activities in humans and non-human primates have generated an enormous amount of information related to evolution, phylogenetics, population genetics, and biomedical research. Elucidation of gene function, expression, and regulation, and of variation and conservation among primate species have exciting potential for informing anthropological investigations in this post-genomic era. This information, together with advanced analytical tools involved in its generation, has tremendous applied value in disciplines such as anthropology and medicine.
The goals of this symposium are twofold: 1) it will provide an overview of the state-of-the-art molecular, epidemiologic, and statistical genetic techniques currently used to dissect the genetic architecture of complex phenotypes, both normal and disease-related, using data from both human and non-human primates, and 2) it will present examples of successful and ongoing applications of these methods to traits of particular interest in biological anthropology using a broad array of analytical tools.
| Time |
Topic
and
Speaker(s) |
| 8:00 am |
Current trends in
human genomic science in relation to the dissection of human variation.
J. BLANGERO. |
| 8:15 am | Sequencing the genomes of nonhuman primates: Progress and future. J. ROGERS. |
| 8:30 am |
Gene mapping and analytical techniques: Localization of genes that shape human variation. L. ALMASY. |
| 8:45 am | Expression profiling: A new approach for understanding the determinants of human variation. H.H.H. GöRING. |
| 9:00 am | Comparative genomics:
tools for study of complex diseases. L. COX. |
| 9:15 am | Genetics of
cardiovascular disease in non-human primates. M.C. MAHANEY AND A.G.
COMUZZIE. |
| 9:30 am | Variation, genetics,
and evolution of the primate craniofacial complex. R.J. SHERWOOD, M.C.
MAHANEY, D.L. DUREN, L. M. HAVILL, L.A. COX, J. ROGERS AND B. TOWNE. |
| 9:45 am |
Break |
| 10:00 am | Genetic influences on
behavior in non-human primates. J.N. BAILEY AND L.A. FAIRBANKS. |
| 10:15 am | Genetics of
bone-related phenotypes in non-human primates. L.M. HAVILL AND J.A.K.
HARRIS. |
| 10:30 am | Population Structure
Measured by Molecular Genetic Markers: Aleutian Archipelago. M.H.
CRAWFORD, A.J. REDD AND M. ZLOJUTRO. |
| 10:45 am | Genetics of Type 2 Diabetes and the Metabolic Syndrome in Mexican Americans. C.P JENKINSON, R. ARYA AND R. DUGGIRALA. |
| 11:00 am | Genetics of
cardiovascular disease in minority populations. J.W. MACCLUER, S.A.
COLE, A.G. COMUZZIE, J. BLANGERO, AND B.V. HOWARD. |
| 11:15 am | Genetics of
behavioral traits and psychiatric disease in human populations. D.C.
GLAHN. |
| 11:30 am | Genomic studies of
human populations: Resequencing approaches for the identification of
human quantitative loci. J.E. CURRAN. |
| 11:45 am | Discussants: S.
WILLIAMS-BLANGERO AND A.G. COMUZZIE. |